Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box)
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Trifexis Chewable Tablet for Dogs, 10.1-20 lbs, (Orange Box)

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Vendor: Trifexis
SKU: 296785
$309.23 $282.72
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Categories: Dog, Pet Supplies,

Product Type: Flea & Tick




Item Number 296785
Common Brand Name(s) Trifexis, Comfortis
For Use With Dogs
Generic Name Spinosad, Milbemycin Oxime
Administration Form Oral
Repels or Prevents Fleas, Heartworms
Kills or Treats Fleas, Roundworms, Hookworms, Whipworms
Breed Size Small Breeds
Product Form Chewable Tablet
Strength 270 mg Spinosad and 4.5 mg Milbemycin Oxime
Health Condition Heartworms, Fleas, Hookworms, Roundworms, Whipworms
Drug Type Parasiticide


Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Possible Side Effects

When used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.

Drug & Food Interactions

Always communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.


The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing


270 mg Spinosad and 4.5 mg Milbemycin Oxime.


placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.

Storage Instructions

Store at controlled room temperatures between 68° - 77°F.